The Results of the Study on Prenatal Estrogen-Testosterone Imbalance as a Risk Factor in the Development of Headache from Medication Overuse Headache

Abstract

This article highlights the significance of prenatal estrogen-testosterone balance as a risk factor in the genesis and early diagnosis of medication overuse headache (often referred to as abuse headache) in primary headaches such as migraine and tension headache. To date, while there is information regarding the origin and development of medication overuse headache, the role and significance of prenatal sex steroid hormones as risk factors have not been fully clarified. In these instances, it is crucial to investigate not only the sexual hormonal imbalance during puberty but also alterations during the prenatal period.