Formulation and Evaluation of Antimicrobial Nail Lacquer for the Treatment of Paronychia and Onychomycosıs

Abstract

Onychomycosis and Paronychia are nail infections caused by fungal and bacterial species respectively. In the present work, a medicated antimicrobial nail lacquer containing Oleuropein has been developed. The nail lacquer formulation was prepared by simple mixing and it was analyzed for non-volatile content, gloss, smoothness, viscosity, water resistance, drug diffusion studies, antimicrobial susceptibility studies against common fungal and bacterial organisms. Among all formulation, nail lacquer prepared with 3.5% Oleuropein, 7% ethyl cellulose, 15 % salicylic acid, 10% ethyl acetate exhibited better non-volatile content, drug release, and zone of inhibition. The drug shows complete release of 96.40% at 3 hours. FTIR studies revealed that drug and excipients are compatible. Formulation and usage of these systems are safe, without any complication. So, we conclude that the antifungal nail lacquer may be one of the novel dosage forms that can revolutionize the pharmaceutical and health care sector.