Novel Vesicular Formulation Based on A Herbal Extract Loaded With Niosomes and Evaluation of Its Anti-Fungal Potential

Abstract

Current scientific technologies are merged with herbal drug-loaded delivery systems to improve the therapeutic value of pharmaceuticals. This study aims to develop and assess a niosomal drug delivery system based on hydro-alcoholic root extract of Leonotis nepetaefolia (L.) R.Br. Particle size entrapment efficiency and in-vitro drug release studies were used to analyse the niosomal dispersion. The use of niosomal formulations for drug administration is becoming more and more popular these days, and Leonotis nepetaefolia (L.) R.Br. hydro-alcoholic root extract may find a home in this method for treating fungal infections. The most promising formulation, according to the data, was HNF-8, which included Tween 40 as a surfactant in a 2:1 ratio with cholesterol.