Synthesis of 3,5,6-Substituted Uridine Derivatives as Potential Therapeutic Agents

Abstract

This study focuses on uridine derivatives with modifications at specific positions on the molecule, particularly at the 3rd, 5th, and 6th carbons. These modified uridines serve two main purposes of Intermediate Building Blocks and Potential Cancer Treatment They act as helpful intermediates, essentially building blocks, for the synthesis of even more complex uridine derivatives with additional substitutions.These substituted uridines themselves hold promise as therapeutic agents, particularly in tumor treatment. However, further research is needed to fully explore their effectiveness and potential applications. Despite being discovered in 1959 and demonstrating impressive effectiveness against malignant tumors (U.S. Pat. No.2885398), 5-fluorouridine's high toxicity has limited its clinical application. 5-Trifluoromethyl-2'-deoxyuridine (5-CF3dUrd) demonstrates both anti-tumor activity (Cancer Research 24, 1979 [1964]) and antiviral properties (Cancer Research 30, 1549, 1970). These promising findings have fueled research into the potential therapeutic applications of 5-CF3dUrd and related derivatives. This study details the synthesis of several substituted uridine derivatives using various approaches. The structures of these newly synthesized molecules were confirmed using ¹H-NMR and mass spectrometry. Our findings suggest that these derivatives possess potential as promising drug candidates for further evaluation in relevant therapeutic areas.