Tackling MDRSA: Biotechnological Approaches to Combat Multi-Drug Resistant Staphylococcus aureus

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Rahul M. Sonavale, Wasim A. Bagwan, Dhanshri Vishal Patil


Multi-Drug Resistant Staphylococcus aureus (MDRSA) poses a significant challenge to healthcare systems worldwide, leading to increased morbidity, mortality, and healthcare costs. Traditional antibiotic therapies are becoming less effective against MDRSA strains due to their ability to develop resistance mechanisms. Biotechnological approaches offer promising avenues for combating MDRSA by leveraging advancements in molecular biology, genomics, and synthetic biology. This paper reviews recent biotechnological strategies aimed at overcoming MDRSA, including the development of novel antimicrobial peptides, phage therapy, CRISPR-Cas systems for targeted genome editing, and the exploration of alternative antimicrobial agents derived from natural sources. Furthermore, the challenges and future directions in utilizing biotechnological tools to address MDRSA are discussed, highlighting the importance of interdisciplinary collaborations and innovative research in combating this global health threat.

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