Gene Therapy Innovations: A New Frontier in Cancer Biology Treatment

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Shilpa S. Ruikar, Snehal A. Masurkar, Abhay A.Ghatage


This paper delves into the transformative potential of gene therapy in the realm of oncology, highlighting its emergence as a frontier in the fight against cancer. Gene therapy, by targeting the genetic underpinnings of cancer, offers a novel approach to treatment that surpasses the limitations of traditional therapies such as chemotherapy, radiation, and surgery. Through mechanisms like gene replacement, silencing, editing, and immunomodulation, gene therapy aims to correct the genetic abnormalities driving cancer progression, offering a more personalized and precise treatment modality. Despite its promise, the path to integrating gene therapy into mainstream cancer treatment is fraught with challenges. Technical hurdles include ensuring targeted delivery and managing immune responses, while ethical, regulatory, and access issues present additional complexities. The paper outlines the current advancements in gene therapy, including CRISPR-Cas9 gene editing and CAR-T cell therapy, and discusses the ongoing challenges and strategic priorities necessary for advancing gene therapy in oncology. Addressing these challenges requires a multidisciplinary approach, emphasizing the need for collaborative research, ethical governance, and efforts to improve access and affordability. The paper argues for a future where gene therapy is a cornerstone of cancer treatment, transforming patient care through more effective, personalized, and less invasive treatments. In conclusion, gene therapy represents a significant leap forward in oncology, offering hope for more effective cancer treatments. By navigating the scientific, ethical, and logistical hurdles, the promise of gene therapy can be realized, ushering in a new era of cancer care that is more targeted, more effective, and accessible to patients worldwide.

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