Study the Role of Mirna146a and Some Interleukins as Important Markers in Patients with a Thyroid Disorder

Abstract

MicroRNAs (miRNAs) are a class of non-coding RNAs approximately 19–24 nucleotides in length that can function as oncogenes or tumour suppressors by inhibiting the translation of tumour suppressor genes or by blocking the translation of oncogenes. 120 samples were collected from the governorate of Najaf (60 with thyroidectomy and 60 as controls) to identify Using miRNA146a as an indicator for primary of thyroid cancer. The proportion of patients was over the expiration of miRNA146a as (2.32±0.12)   compared to the control group (1±0.07)),. This study also by using the ELISA technique for interleukin 6 and tumor necrotic factor alpha (TNFα) as markers for thyroid disorder This study show the high significance of interleukin 6 (IL6) and tumor necrotic factor alpha (TNFα) as (p-value 0.002) and (p-0.004) respectively.