Formulation and Evaluation of Pulsatile Drug Delivery for Nocturnal Acid Breakthrough Using Famotidine

Abstract

The development of a floating-pulsatile drug delivery system for famotidine aims to enhance therapeutic efficacy and patient compliance by synchronizing drug release with circadian Famotidine ythms in acid secretion. Current systems for Famotidine fail to adequately align drug release with circadian Famotidine ythms, potentially limiting treatment effectiveness and patient adherence. This study focused on developing a novel floatingpulsatile drug delivery system for Famotidine that achieves controlled release synchronized with circadian acid secretion patterns. Preformulation studies assessed Famotidine stability and excipient compatibility, followed by direct compression of core tablets. These tablets were then coated with ethyl cellulose and hydroxypropyl methylcellulose to achieve pulsatile release, supplemented with coatings for effervescence and gastric buoyancy. The resulting formulation exhibited a burst release pattern after a predetermined lag time, maintaining buoyancy in the gastric environment and effectively synchronizing drug release with circadian Famotidine ythms. This innovative approach holds promise for improving therapeutic outcomes and patient compliance in Famotidine treatment, particularly in managing gastric disorders.